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Rapid Prototyping of Miniaturized Powder Mixing Geometries.

Authors
  • Svane, Rasmus1
  • Pedersen, Troels1
  • Hirschberg, Cosima1
  • Rantanen, Jukka2
  • 1 Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark. , (Denmark)
  • 2 Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark. Electronic address: [email protected] , (Denmark)
Type
Published Article
Journal
Journal of Pharmaceutical Sciences
Publisher
Elsevier
Publication Date
Jul 01, 2021
Volume
110
Issue
7
Pages
2625–2628
Identifiers
DOI: 10.1016/j.xphs.2021.03.019
PMID: 33775671
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Continuous manufacturing is an important element of future manufacturing solutions enabling for both high product quality and streamlined development process. The increasing possibilities with computer simulations allow for innovating novel mixing principles applicable for continuous manufacturing. However, these innovative ideas based on simulations need experimental validation. The use of rapid prototyping based on additive manufacturing opens a possibility to evaluate these ideas at a low cost. In this study, a novel powder mixing geometry was prototyped using additive manufacturing and further, interfaced with an in-line near-IR spectrometer allowing for investigating the residence time distribution (RTD) in this geometry. Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

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