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Rapid engraftment after allogeneic transplantation of density-enriched peripheral blood CD34+ cells in patients with advanced hematologic malignancies.

Authors
  • Cao, T M
  • Kusnierz-Glaz, C
  • Valone, F
  • Stockerl-Goldstein, K E
  • Hu, W W
  • Johnston, L
  • Blume, K G
  • Strober, S
  • Negrin, R S
Type
Published Article
Journal
Cancer
Publication Date
Jun 15, 2001
Volume
91
Issue
12
Pages
2205–2213
Identifiers
PMID: 11413507
Source
Medline
License
Unknown

Abstract

These data suggest that T-cell subset manipulation via density gradient separation is a safe procedure and allowed rapid hematopoietic recovery. Selective enrichment of a donor DN T-cell subset was observed in only a few and was not associated with a reduced incidence of GVHD. However, the low-density selected cells still resulted in GVHD, and there was a high treatment-related mortality.

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