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Rapid diagnosis of alcoholic ketoacidosis by proton NMR.

Authors
Type
Published Article
Journal
Intensive care medicine
Publication Date
Volume
27
Issue
4
Pages
785–786
Identifiers
PMID: 11398710
Source
Medline
License
Unknown

Abstract

In alcoholic patients, metabolic acidosis can be related to lactate acidosis associated with sepsis or thiamine deficiency, ketoacidosis, methanol or ethylene glycol poisoning. High resolution proton nuclear magnetic resonance (NMR) can be used to detect abnormal organic acid metabolites in urine or serum from patients with various metabolic disorders. In the present case, a 26-year-old patient was admitted for a coma associated with severe metabolic acidosis. Alcoholic ketoacidosis (AKA) was identified by urine proton NMR. Her metabolic disorders rapidly improved. Persisting associated neurological alteration was related to extrapontine myelinolysis as shown by imaging cerebral NMR.

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