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Rapid Detection of Mutations in the 23S rRNA Gene of Helicobacter pylori That Confers Resistance to Clarithromycin Treatment to the Bacterium

Authors
  • Masayuki Matsumura
  • Yoko Hikiba
  • Keiji Ogura
  • Goichi Togo
  • Izumi Tsukuda
  • Kenji Ushikawa
  • Yasushi Shiratori
  • Masao Omata
Publisher
American Society for Microbiology
Publication Date
Feb 01, 2001
Source
PMC
Keywords
Disciplines
  • Medicine
License
Unknown

Abstract

We developed a new method capable of detecting point mutations in the 23S rRNA gene of Helicobacter pylori using a LightCycler. Our method can detect a mutation in this gene in less than 1 h and can process many samples at once, thereby contributing to the selection of patients suitable for clarithromycin-based therapy.

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