The effects of 46 drugs on luminol-dependent chemiluminescence of human whole blood leucocytes during phagocytosis were studied. Anti-inflammatory agents, antihistaminics and anticoagulants inhibited the chemiluminescent phagocytic response of leucocytes (CPRL) at concentrations comparable with therapeutic ones. LD50/ED50 (CPRL inhibition) factor of 3 is offered as the screening threshold for a number of nonsteroidal anti-inflammatory drugs. The possibility of using anticoagulants and anaprilin for the effect of resorption of myocardial infarction was postulated.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/2663543