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[Rapid chemiluminescence analysis of the effect of drugs on the functional activity of phagocytosing blood cells].

Authors
Type
Published Article
Journal
Farmakologiia i toksikologiia
Publication Date
Volume
52
Issue
2
Pages
97–100
Identifiers
PMID: 2663543
Source
Medline
License
Unknown

Abstract

The effects of 46 drugs on luminol-dependent chemiluminescence of human whole blood leucocytes during phagocytosis were studied. Anti-inflammatory agents, antihistaminics and anticoagulants inhibited the chemiluminescent phagocytic response of leucocytes (CPRL) at concentrations comparable with therapeutic ones. LD50/ED50 (CPRL inhibition) factor of 3 is offered as the screening threshold for a number of nonsteroidal anti-inflammatory drugs. The possibility of using anticoagulants and anaprilin for the effect of resorption of myocardial infarction was postulated.

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