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Rapid alterations in neuroimmune gene expression after acute ethanol: Timecourse, sex differences and sensitivity to cranial surgery.

Authors
  • Gano, Anny1
  • Mondello, Jamie E1
  • Doremus-Fitzwater, Tamara L2
  • Deak, Terrence3
  • 1 Developmental Exposure Alcohol Research Center (DEARC), Behavioral Neuroscience Program, Department of Psychology, Binghamton University, Binghamton, NY 13902-6000, United States of America. , (United States)
  • 2 Department of Psychology, Williams Hall, Ithaca College, 953 Danby Road, Ithaca, NY 14850, United States of America. , (United States)
  • 3 Developmental Exposure Alcohol Research Center (DEARC), Behavioral Neuroscience Program, Department of Psychology, Binghamton University, Binghamton, NY 13902-6000, United States of America. Electronic address: [email protected] , (United States)
Type
Published Article
Journal
Journal of neuroimmunology
Publication Date
Oct 15, 2019
Volume
337
Pages
577083–577083
Identifiers
DOI: 10.1016/j.jneuroim.2019.577083
PMID: 31675629
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Prior work has established that that an acute ethanol challenge mimicking high intensity alcohol consumption increased IL-6 and suppressed IL-1β and TNFα mRNA in intoxication, with the opposite pattern seen in withdrawal. These experiments utilized Sprague-Dawley rats to further extend these results across time course (from 45 min to 6 h after ethanol), sex, and central versus peripheral expression. Furthermore, these data show that cannulation surgery may selectively modify the central neuroimmune response to ethanol. These findings highlight a unique plasticity of IL-6 that is specific to central structures and responsive to alterations by environmental factors. Copyright © 2019 Elsevier B.V. All rights reserved.

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