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Rantes production during development of cardiac allograft vasculopathy.

Authors
  • Yun, J J
  • Fischbein, M P
  • Laks, H
  • Irie, Y
  • Espejo, M L
  • Fishbein, M C
  • Berliner, J A
  • Ardehali, A
Type
Published Article
Journal
Transplantation Journal
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Jun 15, 2001
Volume
71
Issue
11
Pages
1649–1656
Identifiers
PMID: 11435978
Source
Medline
License
Unknown

Abstract

We present evidence that other cell types in addition to CD4+, CD8+ T lymphocytes, and CD11b+ macrophages contribute significantly to RANTES production in CAV. In this MHC II-mismatched murine model of CAV, sustained RANTES production requires CD4+ lymphocytes, correlates with mononuclear cell recruitment, and precedes intimal thickening. In experimental and human CAV, vessel wall cells may also produce RANTES. Interventions aimed at inhibiting RANTES production in CAV may need to target several types of cells, and neutralization of RANTES bioactivity may reduce mononuclear cell recruitment and CAV development.

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