Affordable Access

Access to the full text

Ranking cancer drivers via betweenness-based outlier detection and random walks

Authors
  • Erten, Cesim1
  • Houdjedj, Aissa1
  • Kazan, Hilal1
  • 1 Antalya Bilim University, Antalya, Turkey , Antalya (Turkey)
Type
Published Article
Journal
BMC Bioinformatics
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Feb 10, 2021
Volume
22
Issue
1
Identifiers
DOI: 10.1186/s12859-021-03989-w
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundRecent cancer genomic studies have generated detailed molecular data on a large number of cancer patients. A key remaining problem in cancer genomics is the identification of driver genes.ResultsWe propose BetweenNet, a computational approach that integrates genomic data with a protein-protein interaction network to identify cancer driver genes. BetweenNet utilizes a measure based on betweenness centrality on patient specific networks to identify the so-called outlier genes that correspond to dysregulated genes for each patient. Setting up the relationship between the mutated genes and the outliers through a bipartite graph, it employs a random-walk process on the graph, which provides the final prioritization of the mutated genes. We compare BetweenNet against state-of-the art cancer gene prioritization methods on lung, breast, and pan-cancer datasets.ConclusionsOur evaluations show that BetweenNet is better at recovering known cancer genes based on multiple reference databases. Additionally, we show that the GO terms and the reference pathways enriched in BetweenNet ranked genes and those that are enriched in known cancer genes overlap significantly when compared to the overlaps achieved by the rankings of the alternative methods.

Report this publication

Statistics

Seen <100 times