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A randomised controlled trial of propofol vs. thiopentone and desflurane for fatigue after laparoscopic cholecystectomy.

Authors
  • Nostdahl, T1
  • Fredheim, O M2, 3, 4
  • Bernklev, T5, 6
  • Doksrod, T S1
  • Mohus, R M7
  • Raeder, J6, 8
  • 1 Department of Anaesthesiology, Telemark Hospital, Skien, Norway. , (Norway)
  • 2 Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway. , (Norway)
  • 3 Centre of Palliative Medicine, Surgical Division, Akershus University Hospital, Lørenskog, Norway. , (Norway)
  • 4 National Competence Centre for Complex Symptom Disorders, Department of Pain and Complex Disorders, Trondheim, Norway. , (Norway)
  • 5 Research and Development, Vestfold Hospital Trust, Tønsberg, Norway. , (Norway)
  • 6 Institute of Clinical Medicine, Medical Faculty, University of Oslo, Oslo, Norway. , (Norway)
  • 7 Department of Anaesthesiology, St. Olav University Hospital, Trondheim, Norway. , (Norway)
  • 8 Department of Anaesthesiology, Oslo University Hospital, Oslo, Norway. , (Norway)
Type
Published Article
Journal
Anaesthesia
Publisher
Wiley (Blackwell Publishing)
Publication Date
Jul 01, 2017
Volume
72
Issue
7
Pages
864–869
Identifiers
DOI: 10.1111/anae.13909
PMID: 28444779
Source
Medline
Keywords
License
Unknown

Abstract

Fatigue may delay functional recovery after day surgery and may be more common after propofol anaesthesia. We randomly allocated 123 participants scheduled for ambulatory laparoscopic cholecystectomy to induction and maintenance of general anaesthesia with propofol or thiopentone and desflurane. Postoperative fatigue was unaffected by the allocated anaesthetic. The combined mean (SD) Identity-Consequences Fatigue Scale of 34.3 (15.1) before surgery increased in the first postoperative week: to 60.4 (21.1) on day 1, p < 0.001; to 51.1 (17.2) on day 2, p < 0.001; and to 37.5 (16.3) on day 6, p = 0.028. The mean (SD) fatigue reduced at one postoperative month to 22.4 (12.6), 35% less than the combined pre-operative level, p < 0.001. Rates of nausea, vomiting and rescue antie-mesis during the first week after propofol, compared with thiopentone and desflurane, were: 23/63 vs. 32/60, p = 0.27; 8/63 vs. 9/60, p = 0.71; and 12/63 vs. 28/60, p = 0.001, respectively. There were no differences in postoperative pain. In conclusion, fatigue after scheduled laparoscopic cholecystectomy was unaffected by anaesthesia with propofol vs. thiopentone and desflurane.

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