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Randomised clinical trial evaluating the effect of different timing and number of fixed timed artificial inseminations, following a seven-day progesterone-based protocol, on pregnancy outcomes in UK dairy heifers.

Authors
  • Walsh, John Paul1, 2
  • Coates, Amy1
  • Lima, Fabio3
  • Smith, Rob1
  • Oikonomou, Georgios1, 4
  • 1 Department of Livestock Health and Welfare, Institute of Veterinary Science, University of Liverpool, Leahurst, Neston, UK.
  • 2 Delaware Veterinary Group, Fulford House, Castle Cary, Somerset, UK.
  • 3 Department of Veterinary Clinical Medicine, University of Illinois Urbana, Champaign, IL, USA.
  • 4 Department of Epidemiology and Population Health, Institute of Infection and Global Health, University of Liverpool, Leahurst, Neston, UK.
Type
Published Article
Journal
Veterinary Record
Publisher
BMJ
Publication Date
Dec 01, 2017
Volume
181
Issue
22
Pages
595–599
Identifiers
DOI: 10.1136/vr.104369
PMID: 28947678
Source
Medline
Keywords
License
Unknown

Abstract

The objective of this study was to determine the effect on pregnancy outcome of either inseminating heifers twice (at 48 and 72 hours after withdrawal of a controlled internal drug release insert (CIDR) containing progesterone) or once (56 hours after CIDR withdrawal) following a seven-day CIDR synchronisation protocol. Dairy heifers (n=267) from five farms, with an age range of 388-736 days, were randomly assigned to one of two treatment groups (group A heifers were inseminated twice; group B heifers were inseminated once). Both groups received a CIDR on day (D) 0 and an intramuscular injection of d-cloprostenol on D6; the CIDR was withdrawn on D7. Measurements of withers height, body condition score and hearth girth (used to estimate weight) were taken on D0. The diameter of the largest follicles and corpora lutea was recorded on both D0 and D6. Data were analysed with the use of multivariable logistic regression modelling. Treatment group and farm were not statistically significantly associated with pregnancy per treatment (P/T). Age and dominant follicle size on D6 were significantly associated with P/T. Heifers with the largest dominant follicle sizes (16-22 mm) were 5.54 times less likely to be pregnant than those heifers with the smallest dominant follicles (8-10 mm) on D6. It was shown that the cost associated with inseminating heifers twice after a seven-day CIDR synchronisation protocol is not justified.

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