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[Raman spectroscopic study of human serum albumin interacting with 3-picolylamine].

Authors
Type
Published Article
Journal
Guang pu xue yu guang pu fen xi = Guang pu
Publication Date
Volume
26
Issue
3
Pages
460–462
Identifiers
PMID: 16830755
Source
Medline
License
Unknown

Abstract

Raman spectra of human serum albumin (HSA) and HSA-3-picolylamine complex were obtained. The spectra indicate the configuration and structural transformations of HSA. The results show that the secondary structure is main alpha-helix, and the binding of 3-picolylamine doesn't change the secondary structure. However, the binding changes the configuration of disulfide bonds, transforms a single tryptophan residue from exposed tryptophan residues to hydrophobic environment, and alters the microenvironment of tyrosine.

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