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Raman scattering in pathology.

Authors
  • Smith, Zachary J
  • Huser, Thomas R
  • Wachsmann-Hogiu, Sebastian
Type
Published Article
Journal
Analytical cellular pathology (Amsterdam)
Publication Date
Jan 01, 2012
Volume
35
Issue
3
Pages
145–163
Identifiers
DOI: 10.3233/ACP-2011-0048
PMID: 22155991
Source
Medline
License
Unknown

Abstract

Raman scattering is the inelastic scattering of light by chemical bonds, and can therefore show molecular specificity. It can be used both in pure spectroscopy mode, and in imaging mode. While many applications of Raman spectroscopy and imaging in the biomedical field have been so far demonstrated, the use of this technology for pathology applications is still in early stages. In this paper we review some of the most important recent developments in this field, including a description of relevant technologies, applications to molecular sensing, characterization of cells and tissues of interest, and disease detection via Raman scattering.

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