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[Radioprotective effectiveness and toxicity of 4,5-disubstituted tryptamines].

Authors
  • Korovkina, E P
  • Chernov, G A
  • Vinograd, L Kh
  • Petrunin, I A
  • Suvorov, N N
Type
Published Article
Journal
Radiobiologiia
Publication Date
Jan 01, 1986
Volume
26
Issue
6
Pages
833–836
Identifiers
PMID: 3468557
Source
Medline
License
Unknown

Abstract

In experiments on mice a study was made of different substituents in the 4th position of the indole ring of 5-methoxytryptamines (5-MOT) on toxicity and radioprotective efficiency of the compounds of this class. It was shown that the administration of the amino-group to a mexamine molecule increased the preparation toxicity; the nitro-group somewhat diminished the toxic properties, and the acetylamino group did not change 5-MOT toxicity. A 5-MOT derivative with a nitro group possessed the strongest radioprotective action. The radioprotective efficiency of these compounds persisted for 1-2 h.

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