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Radioprotective Effect of Thymoquinone in X-irradiated Rats

Authors
  • El-Benhawy, Sanaa A.
  • Morsi, Mohamed I.
  • El-Tahan, Rasha A.
  • Matar, Noura A.
  • Ehmaida, Hawa MG
Type
Published Article
Journal
Asian Pacific Journal of Cancer Prevention : APJCP
Publisher
West Asia Organization for Cancer Prevention
Publication Date
Sep 01, 2021
Volume
22
Issue
9
Pages
3005–3015
Identifiers
DOI: 10.31557/APJCP.2021.22.9.3005
PMID: 34582673
PMCID: PMC8850879
Source
PubMed Central
Keywords
Disciplines
  • Research Article
License
Unknown

Abstract

Background: Thymoquinone, has anti-inflammatory, anti-oxidant, and cardio protection properties. This study aimed to evaluate the radioprotective effect of thymoquinone in whole body X-irradiated rats. Methods: This study conducted on 40 male adult Wistar albino rats randomized into the following groups: Group I: Control rats did not receive thymoquinone or ionizing radiation. Group II: Whole-body irradiated rats with 6 Gy of X-ray. Group III: Rats orally intubated with thymoquinone (10 mg/kg/day) for 7 days then subjected to whole-body irradiation with 6 Gy then supplemented with thymoquinone for another 7 days. Group IV: Rats orally intubated with thymoquinone (20 mg/kg/day) for 7 days then subjected to whole-body irradiation with 6 Gy then supplemented with thymoquinone (20 mg/kg/day) for another 7 days. LDH, CK-MB, ALT, AST, MDA, TAC, Catalase activity, GPX, GSR and GSH were measured. Results: Lipid peroxidation biomarker in the blood of X-irradiated rats significantly increased and accompanied by decrease in the levels of GSH, GSR, GPX, catalase as well as TAC. Moreover, exposure to IR significantly increases cardiac and liver enzymes. However, administration of TQ to X-irradiated rats with either 10 mg/kg or 20 mg/kg have the same reform effects and significantly protects rats against adverse effects of IR. Conclusion: Exposure to X-ray leads to significant changes in cellular biochemical and morphological conditions. Administration of TQ before radiation treatment significantly decreases the adverse effects of IR. TQ can improve cardiac function, decrease myocardial enzyme levels and inhibit oxidative stress.

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