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Radiopharmacological profiles of tracers under pathophysiological conditions. 99mTc-methylene diphosphonate uptake by bone in altered thyroid status.

Authors
  • Pahuja, D N
  • Noronha, O P
Type
Published Article
Journal
International Journal of Radiation Applications and Instrumentation Part B Nuclear Medicine and Biology
Publisher
Elsevier
Publication Date
Jan 01, 1988
Volume
15
Issue
5
Pages
573–576
Identifiers
PMID: 3254880
Source
Medline
License
Unknown

Abstract

The uptake of 99mTc-MDP, a skeletal radiotracer, was studied at early and late (3 h) time intervals in rats induced with altered thyroid status. Thyroid dysfunction resulted in disturbances in bone mineral metabolism. Rats rendered hypothyroid showed an overall retardation in growth and also considerably reduced skeletal uptake, especially at early time periods. On the other hand, rats rendered hyperthyroid did not show any significant alteration of the skeletal uptake as compared with controls despite enhanced bone turnover normally observed in hyperthyroidism.

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