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A radiometric assessment of phagocytosis and intracellular killing by blood polymorphonuclear leucocytes in rheumatoid arthritis.

Authors
  • Sheehan, N J
  • Brown, K A
  • Dumonde, D C
Type
Published Article
Journal
British journal of rheumatology
Publication Date
Aug 01, 1984
Volume
23
Issue
3
Pages
198–202
Identifiers
PMID: 6378305
Source
Medline
License
Unknown

Abstract

Disagreement persists about the phagocytic function of blood polymorphonuclear leucocytes (PMN) in rheumatoid arthritis (RA). Many of the experimental data have been generated by subjective methods of assessment. Using a radiometric assay, we found no difference in the phagocytosis and intracellular killing of Candida albicans by blood PMN from 18 patients with RA when compared with PMN from 21 healthy control subjects. We infer that the increased incidence of non-articular infection reported in RA is not related to impaired phagocytic function of blood PMN.

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