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Radiolabeling morpholinos with 90Y, 111In, 188Re and 99mTc.

Authors
  • Liu, Chang-bin
  • Liu, Guo-zheng
  • Liu, Ning
  • Zhang, Yu-min
  • He, Jiang
  • Rusckowski, Mary
  • Hnatowich, Donald J
Type
Published Article
Journal
Nuclear Medicine and Biology
Publisher
Elsevier
Publication Date
Feb 01, 2003
Volume
30
Issue
2
Pages
207–214
Identifiers
PMID: 12623121
Source
Medline
License
Unknown

Abstract

When radiolabeled with DOTA, (90)Y-labeled MORF showed increased instabilities relative to that of (111)In and when radiolabeled with MAG(3), (188)Re showed in vitro and in vivo instabilities compared to (99m)Tc, but all labels were still largely intact after 48 h in saline or serum. Possibly because of the rapid clearance of MORFs, no important differences in biodistribution among (90)Y, (111)In and (99m)Tc labels were evident in normal mice. These strategies for labeling MORF with (90)Y and (188)Re therefore appear to be suitable for therapeutic applications although both show some evidence of instabilities.

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