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Radioimmunodetection of ovarian cancer.

Authors
  • Ahlström, K R
  • Hietala, S O
  • Stendahl, U
  • Stigbrand, T
Type
Published Article
Journal
Acta oncologica (Stockholm, Sweden)
Publication Date
Jan 01, 1993
Volume
32
Issue
7-8
Pages
729–734
Identifiers
PMID: 8305219
Source
Medline
License
Unknown

Abstract

Radioimmunoscintigraphy (RIS) is a potentially valuable method for the detection of primary, secondary and recurrent malignant tumours. Antigens that have been used for monitoring as well as for RIS of ovarian carcinomas include CA 125, PLAP, HMFG, and CA 19-9. Between 70 and 100% of the tumours have been detected at RIS when these antigens have been used. Conventional methods, e.g., computerized tomography (CT) and ultrasonography (US), demonstrate similar or lower detection rate than RIS for tumour diagnosis. RIS gives additional information to conventional radiological methods (CT and US) for the detection of occult ovarian carcinomas. A review of earlier investigations is given and our own recent results using PLAP as a target antigen are presented. The future potential of the technology is discussed.

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