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[Radioimmunodetection of colorectal cancer, using anti-CEA monoclonal antibody CEA102: experience of 20 cases].

Authors
  • Murakami, K
  • Watanabe, T
  • Tadokoro, M
  • Sakamoto, J
  • Murayama, H
  • Wada, K
  • Sakuma, S
  • Takagi, H
Type
Published Article
Journal
Nihon Geka Gakkai zasshi
Publication Date
Feb 01, 1993
Volume
94
Issue
2
Pages
119–127
Identifiers
PMID: 8464409
Source
Medline
License
Unknown

Abstract

The monoclonal antibody CEA 102 against carcinoembryonic antigen was produced by immunization with purified CEA, and used as a radiotracer for the imaging of colorectal cancer. CEA102 was labeled with 131I by the chloramine-T or the Iodogen method, and administered i.v. to 20 patients with liver metastases, local recurrences, and/or primary tumors. Planar scintigraphy was performed during 5 or 6 postinfusion days. Hypersensitivity reactions such as fever and chill occurred in 4 patients, but no side effects were noted after endotoxin was excluded. Overall sensitivity was 71.4% (primary tumor 4/4, liver metastasis 5/6, lymph node metastasis 1/1, local recurrence 5/10), and no false positive was observed. In the cases of local recurrences, this method was useful to distinguish postoperative fibrosis from local recurrence. These results revealed that radiolabeled CEA102 has a great potential in qualitative diagnosis of colorectal cancer.

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