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Radioimmunoassay of hair for determining opiate-abuse histories.

Authors
  • Baumgartner, A M
  • Jones, P F
  • Baumgartner, W A
  • Black, C T
Type
Published Article
Journal
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Publication Date
Jul 01, 1979
Volume
20
Issue
7
Pages
748–752
Identifiers
PMID: 541713
Source
Medline
License
Unknown

Abstract

Heroin and morphine metabolites can be detected in hair with the use of commercially available radioimmunoassay reagents and with minor sample preparation. Hair samples obtained from morphine-treated mice and heroin users contained nanogram levels of the drug per milligram of hair (single human hair). The results of the hair analyses for all subjects admitting the use of heroin were positive, whereas the results of only 30% of thin-layer chromatographic urinanalyses of these same subjects were positive. In addition, differences in drug concentration for sections of hair near the scalp and near the distal end correlated with the length of time the drug had been used. These results exemplify the potential advantages of the use of hair analysis over urine and serum analyses in terms of accessibility, sample stability, and long-term retention of information.

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