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Radiation-induced signaling pathways that promote cancer cell survival (review).

Authors
  • Hein, Ashley L1
  • Ouellette, Michel M1
  • Yan, Ying1
  • 1 Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA.
Type
Published Article
Journal
International Journal of Oncology
Publisher
Spandidos Publications
Publication Date
Nov 01, 2014
Volume
45
Issue
5
Pages
1813–1819
Identifiers
DOI: 10.3892/ijo.2014.2614
PMID: 25174607
Source
Medline
License
Unknown

Abstract

Radiation therapy is a staple cancer treatment approach that has significantly improved local disease control and the overall survival of cancer patients. However, its efficacy is still limited by the development of radiation resistance and the presence of residual disease after therapy that leads to cancer recurrence. Radiation impedes cancer cell growth by inducing cytotoxicity, mainly caused by DNA damage. However, radiation can also simultaneously induce multiple pro-survival signaling pathways, such as those mediated by AKT, ERK and ATM/ATR, which can lead to suppression of apoptosis, induction of cell cycle arrest and/or initiation of DNA repair. These signaling pathways act conjointly to reduce the magnitude of radiation-induced cytotoxicity and promote the development of radioresistance in cancer cells. Thus, targeting these pro-survival pathways has great potential for the radiosensitization of cancer cells. In the present review, we summarize the current literature on how these radiation‑activated signaling pathways promote cancer cell survival.

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