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Radiation-induced gliomas in 2 pediatric patients with neurofibromatosis type 1: case study and summary of the literature.

Authors
  • Madden, Jennifer R
  • Rush, Sarah Z
  • Stence, Nicholas
  • Foreman, Nicholas K
  • Liu, Arthur K
Type
Published Article
Journal
Journal of Pediatric Hematology/Oncology
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Mar 01, 2014
Volume
36
Issue
2
Identifiers
DOI: 10.1097/MPH.0000000000000006
PMID: 24136023
Source
Medline
License
Unknown

Abstract

Neurofibromatosis type 1 (NF1) is a genetic disorder that predisposes patients to the formation of sporadic tumors and also increases the risk of radiation-induced malignancies. The most commonly described radiation-induced tumor in NF1 patients is a malignant peripheral nerve sheath tumor. We present 2 children with NF1 who received radiation therapy and subsequently developed high-grade gliomas. We then review the current literature on radiation-induced tumors in NF1 patients. Although radiation may be the most appropriate therapy in specific situations for children with NF1, the secondary tumor risk should be carefully considered.

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