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Radiation-induced changes in bone perfusion and angiogenesis.

Authors
  • Okunieff, P
  • Wang, X
  • Rubin, P
  • Finkelstein, J N
  • Constine, L S
  • Ding, I
Type
Published Article
Journal
International Journal of Radiation Oncology*Biology*Physics
Publisher
Elsevier
Publication Date
Nov 01, 1998
Volume
42
Issue
4
Pages
885–889
Identifiers
PMID: 9845115
Source
Medline
License
Unknown

Abstract

Radiation induces a chronic antiangiogenic effect contributing to reduced limb growth. At 33 weeks the antiangiogenesis was not associated with local soft tissue elevations of TNF, IFN, or TGFbeta. Radiation toxicity to bone is alleviated by bFGF therapy suggesting that powerful locally-acting antiangiogenic mechanisms are involved. We postulate that the increased LDF of the contralateral tibia is due to circulating angiogenesis factors that are elevated to compensate for the radiation-induced antiangiogenesis.

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