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Racial differences in ocular oxidative metabolism: implications for ocular disease.

Authors
  • Siegfried, Carla J1
  • Shui, Ying-Bo
  • Holekamp, Nancy M
  • Bai, Fang
  • Beebe, David C
  • 1 Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA. [email protected]
Type
Published Article
Journal
Archives of ophthalmology (Chicago, Ill. : 1960)
Publication Date
Jul 01, 2011
Volume
129
Issue
7
Pages
849–854
Identifiers
DOI: 10.1001/archophthalmol.2011.169
PMID: 21746975
Source
Medline
License
Unknown

Abstract

Racial differences in oxygen levels in the human eye reflect an important difference in oxidative metabolism in the cornea and lens and may reflect differences in systemic physiologic function. Increased oxygen or oxygen metabolites may increase oxidative stress, cell damage, intraocular pressure, and the risk of developing glaucoma. Oxygen use by the cornea decreases with age.

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