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(R)-(+)-2-{[(3-Methyl-4-nitro-pyridin-2-yl)meth-yl]sulfin-yl}-1H-benzimidazole.

Authors
  • Naga Raju, Manne
  • Uday Kumar, Neelam
  • Kolla, Naveenkumar
  • Bandichhor, Rakeshwar
  • Vishweshwar, Peddy
Type
Published Article
Journal
Acta Crystallographica Section E Structure Reports Online
Publisher
International Union of Crystallography
Publication Date
Aug 01, 2011
Volume
67
Issue
Pt 8
Identifiers
DOI: 10.1107/S1600536811029990
PMID: 22091198
Source
Medline
License
Unknown

Abstract

The title compound, C(14)H(12)N(4)O(3)S, is an inter-mediate of Dexlansoprazole, a proton pump inhibitor (PPI) mainly developed for anti-ulcer activity. The absolute configuration of the title compound was determined as R. The crystal structure reveals that the mol-ecules form chains along the b axis through N-H⋯N and C-H⋯O hydrogen-bonded dimers. These chains are connected via weak C-H⋯O hydrogen bonds.

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