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Quinones from Chirita eburnea.

Authors
  • Cai, Xiang-Hai
  • Luo, Xiao-Dong
  • Zhou, Jun
  • Hao, Xiao-Jiang
Type
Published Article
Journal
Journal of natural products
Publication Date
May 01, 2005
Volume
68
Issue
5
Pages
797–799
Identifiers
PMID: 15921435
Source
Medline
License
Unknown

Abstract

Five new quinone derivatives, (R)-7-hydroxy-alpha-dunnione (1), (R)-8-hydroxy-alpha-dunnione (2), (R)-7,8-dihydroxy-alpha-dunnione (3), (R)-7-methoxy-6,8-dihydroxy-alpha-dunnione (4), and 1,7-dihydroxy-2-hydroxymethylanthraquinone (5), along with seven known compounds, were isolated from Chirita eburnea. All structures were elucidated by spectroscopic techniques (NMR, MS, UV, and IR). The EtOAc fraction of the EtOH extract and compounds 3 and 4 showed free radical (DPPH) scavenging activity, with IC50 values of 101.7 +/- 5.2 microg/mL, 124.82 +/- 8.4 microM, and 45.72 +/- 3.6 microM, respectively, compared with 86.91 +/-6.8 microM for ascorbate.

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