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Quinoline-based Compounds as Key Candidates to Tackle Drug Discovery Programs of Microbicidal Agents.

Authors
  • da Gama, Aline N Silva1
  • Soeiro, Maria N C1
  • 1 Laboratorio de Biologia Celular, Instituto Oswaldo Cruz, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil. , (Brazil)
Type
Published Article
Journal
Current pharmaceutical design
Publication Date
Jan 01, 2021
Volume
27
Issue
15
Pages
1757–1762
Identifiers
DOI: 10.2174/1381612826666201006125644
PMID: 33023440
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Quinolines are heterocyclic nitrogen compounds, ubiquitous in nature and largely used as a structural component of dyes, solvent for resins, terpenes as well as during the production of several other chemical stuffs, including pesticides. Quinolines, such as quinine and chloroquine, exhibit various pharmacological properties, acting as antimalarial drugs, antiparasitic, antibacterial, antiviral, antifungal, and anticancer agents, besides being in clinical use for autoimmune diseases. A brief review has been presented regarding the biological effect and clinical use of quinolines and derivatives upon three trypanosomatids agents of important neglected tropical diseases; Trypanosoma cruzi, Trypanosoma brucei spp and Leishmania spp, which trigger Chagas disease, sleeping sickness and leishmaniasis, respectively, also extending to a glance update of their potential application towards other microbes relevant for emerging illness caused by fungi, bacteria and virus, including the pandemic Covid-19. Copyright© Bentham Science Publishers; For any queries, please email at [email protected]

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