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Quinine 3-hydroxylation as a biomarker reaction for the activity of CYP3A4 in man.

Authors
  • Mirghani, Rajaa A
  • Ericsson, Orjan
  • Tybring, Gunnel
  • Gustafsson, Lars L
  • Bertilsson, Leif
Type
Published Article
Journal
European journal of clinical pharmacology
Publication Date
May 01, 2003
Volume
59
Issue
1
Pages
23–28
Identifiers
PMID: 12743670
Source
Medline
License
Unknown

Abstract

The MR of quinine in plasma or urine may serve as a stable measure of the activity of CYP3A4 in man. These results together with in vitro data show that quinine is also a specific CYP3A4 probe.

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