Based on these clinical trials and guidelines, we conclude that the best treatment currently is the use of antibiotics in patients with severe acute pancreatitis with more than 30% of pancreatic necrosis. The best option for the treatment is Imipenem 3 x 500 mg/day i.v. for 14 days. Alternatively, Ciprofloxacin 2 x 400 mg/day i.v. associated with Metronidazole 3 x 500 mg for 14 days can also be considered as an option.