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The quest to identify the mechanism underlying adrenergic regulation of cardiac Ca2+ channels.

Authors
  • Roybal, Daniel1, 2
  • Hennessey, Jessica A1
  • Marx, Steven O1, 2
  • 1 Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, USA.
  • 2 Department of Pharmacology, Columbia University, Vagelos College of Physicians and Surgeons.
Type
Published Article
Journal
Channels
Publisher
Landes Bioscience
Publication Date
Dec 01, 2020
Volume
14
Issue
1
Pages
123–131
Identifiers
DOI: 10.1080/19336950.2020.1740502
PMID: 32195622
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Activation of protein kinase A by cyclic AMP results in a multi-fold upregulation of CaV1.2 currents in the heart, as originally reported in the 1970's and 1980's. Despite considerable interest and much investment, the molecular mechanisms responsible for this signature modulation remained stubbornly elusive for over 40 years. A key manifestation of this lack of understanding is that while this regulation is readily apparent in heart cells, it has not been possible to reconstitute it in heterologous expression systems. In this review, we describe the efforts of many investigators over the past decades to identify the mechanisms responsible for the β-adrenergic mediated activation of voltage-gated Ca2+ channels in the heart and other tissues.

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