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Quaternary substituted PDE4 inhibitors I: the synthesis and in vitro evaluation of a novel series of oxindoles.

Authors
  • Hulme, C
  • Poli, G B
  • Huang, F C
  • Souness, J E
  • Djuric, S W
Type
Published Article
Journal
Bioorganic & Medicinal Chemistry Letters
Publisher
Elsevier
Publication Date
Jan 20, 1998
Volume
8
Issue
2
Pages
175–178
Identifiers
PMID: 9871649
Source
Medline
License
Unknown

Abstract

The following letter presents the synthesis and in vitro evaluation of a novel quaternary substituted series of phosphodiesterase type (IV) (PDE4) inhibitors. The compounds represent conformationally constrained analogues of the Celltech PDE IV inhibitor, CDP 840. Examples with sub-micromolar IC50's for PDE4 inhibition are reported.

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