Quaternary substituted PDE4 inhibitors I: the synthesis and in vitro evaluation of a novel series of oxindoles.
- Authors
- Type
- Published Article
- Journal
- Bioorganic & Medicinal Chemistry Letters
- Publisher
- Elsevier
- Publication Date
- Jan 20, 1998
- Volume
- 8
- Issue
- 2
- Pages
- 175–178
- Identifiers
- PMID: 9871649
- Source
- Medline
- License
- Unknown
Abstract
The following letter presents the synthesis and in vitro evaluation of a novel quaternary substituted series of phosphodiesterase type (IV) (PDE4) inhibitors. The compounds represent conformationally constrained analogues of the Celltech PDE IV inhibitor, CDP 840. Examples with sub-micromolar IC50's for PDE4 inhibition are reported.
