Affordable Access

Quasispecies nature of an unusual avian paramyxovirus type-1 isolated from pigeons.

Authors
  • Barbezange, Cyril
  • Jestin, Véronique
Type
Published Article
Journal
Virus genes
Publication Date
May 01, 2005
Volume
30
Issue
3
Pages
363–370
Identifiers
PMID: 15830155
Source
Medline
License
Unknown

Abstract

An avian paramyxovirus type-1 (APMV-1) was classified as virulent according to its Intra Cerebral Pathogenicity Index (ICPI), but as avirulent according to the motif of its F protein cleavage site. Although this atypical APMV-1 was isolated from sick, unvaccinated pigeons, it was not grouped with pigeon variants regarding its antigenic and genetic characterisation. We analysed its quasispecies nature by cloning and sequencing parts of the genome in three different genes to evaluate if heterogeneity might explain the difference observed between the ICPI and the F protein cleavage site motif. Two distinct sub-populations were detected in the phosphoprotein gene. In the fusion protein gene, two clones were found to be related to typical pigeon variants in the hypervariable domain.

Report this publication

Statistics

Seen <100 times