Quantum description of mulitiparticle nano-systems is studied in a hot and dense electromagnetic medium. We use renormalization techniques of quantum field theory to show that the electromagnetic properties like electric permittivity and magnetic permeability depend on the temperature and density of the media. Casimir force also depends upon the physical properties of the medium and becomes a function of these parameters within the nano-systems. We discuss the effect of the Casimir force on the nanosystems in terms of temperature and density of the system. We present carbon nanotubes and biomolecules as examples.