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Quantitative trait locus mapping of genetic modifiers of metabolic syndrome and atherosclerosis in low-density lipoprotein receptor-deficient mice: identification of a locus for metabolic syndrome and increased atherosclerosis on chromosome 4.

Authors
  • Seidelmann, Sara Bretschger
  • De Luca, Carl
  • Leibel, Rudolph L
  • Breslow, Jan L
  • Tall, Alan R
  • Welch, Carrie L
Type
Published Article
Journal
Arteriosclerosis Thrombosis and Vascular Biology
Publisher
Ovid Technologies Wolters Kluwer -American Heart Association
Publication Date
Jan 01, 2005
Volume
25
Issue
1
Pages
204–210
Identifiers
PMID: 15514201
Source
Medline
License
Unknown

Abstract

The PERA strain is highly susceptible to the development of metabolic syndrome after feeding a Western-type diet. This susceptibility is due, in part, to a locus on murine chromosome 4 in which PERA alleles predispose to adiposity, increased insulin, and accelerated atherogenesis in the absence of marked hyperlipidemia.

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