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Quantitative study of aluminum binding to human serum albumin and transferrin by a chelex competitive binding assay.

Authors
  • Bertholf, R L
  • Wills, M R
  • Savory, J
Type
Published Article
Journal
Biochemical and biophysical research communications
Publication Date
Dec 28, 1984
Volume
125
Issue
3
Pages
1020–1024
Identifiers
PMID: 6517930
Source
Medline
License
Unknown

Abstract

Binding of aluminum to human serum albumin and transferrin was investigated using a competitive binding assay incorporating a cation exchange resin, chelex. Both albumin and transferrin were found to produce linear Scatchard plots of aluminum binding data over the aluminum and protein concentration ranges found in humans. Binding constants measured for albumin and transferrin were 1.96 and 0.515 microM, respectively.

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