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Quantitative measurement of delayed hypersensitivity in the guinea pig paw.

Authors
  • Förster, O
  • Lindner, A
  • Nitulescu, G
  • Plenk, H Jr
Type
Published Article
Journal
Pharmacology
Publication Date
Jan 01, 1975
Volume
13
Issue
4
Pages
317–324
Identifiers
PMID: 1187756
Source
Medline
License
Unknown

Abstract

To facilitate quantitative measurement of a delayed hypersensitivity reaction, a tuberculin reaction was produced in the paws of sensitized guinea pigs and the resulting edema estimated by one of the usual techniques. The edema formation was shown to be an expression of the delayed hypersensitivity reaction. Optimal conditions for this reaction were assessed. This model may be used for testing the influence of drugs on delayed hypersensitivity reactions.

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