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The quantitative investigation of the binding process of calcium blocking drugs in a sinoatrial node.

Authors
  • Plonsey, R
  • Starmer, C F
  • Tipans, I
Type
Published Article
Journal
Journal of theoretical biology
Publication Date
Mar 07, 1991
Volume
149
Issue
1
Pages
55–61
Identifiers
PMID: 1881146
Source
Medline
License
Unknown

Abstract

Application of existing models of sinoatrial node pacemaker activity and of channel-drug interaction allow us to reproduce action potential changes as a result of the blocking effect of drugs. Two calcium antagonistic drugs, nifedipine and mesudipine, were investigated and as a result averaged rate constants of binding and unbinding were evaluated. The procedure applied which is based on experimental results and on computer simulations, can be used as an initial step for comparison of different drugs.

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