The quantitative investigation of the binding process of calcium blocking drugs in a sinoatrial node.
- Published Article
Journal of theoretical biology
- Publication Date
Mar 07, 1991
Application of existing models of sinoatrial node pacemaker activity and of channel-drug interaction allow us to reproduce action potential changes as a result of the blocking effect of drugs. Two calcium antagonistic drugs, nifedipine and mesudipine, were investigated and as a result averaged rate constants of binding and unbinding were evaluated. The procedure applied which is based on experimental results and on computer simulations, can be used as an initial step for comparison of different drugs.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/1881146