Affordable Access

deepdyve-link
Publisher Website

Quantitative evaluation of postintervention foot blood supply in patients with peripheral artery disease by computed tomography perfusion.

Authors
  • Li, Ming1
  • Li, Zheng2
  • Gao, Pan3
  • Jin, Liang3
  • Li, Li2
  • Zhao, Wei4
  • Zhang, Wan2
  • Sun, Yingli3
  • Zhao, Yun2
  • Cui, Jiasen5
  • 1 Department of Radiology, Huadong Hospital Affiliated to Fudan University, Shanghai, China; Diagnosis and Treatment Center of Small Lung Nodules, Huadong Hospital Affiliated to Fudan University, Shanghai, China; Institute of Functional and Molecular Medical Imaging, Fudan University, Shanghai, China. , (China)
  • 2 Department of Vascular Surgery, Huadong Hospital Affiliated to Fudan University, Shanghai, China. , (China)
  • 3 Department of Radiology, Huadong Hospital Affiliated to Fudan University, Shanghai, China. , (China)
  • 4 Department of Radiology, Huadong Hospital Affiliated to Fudan University, Shanghai, China; Diagnosis and Treatment Center of Small Lung Nodules, Huadong Hospital Affiliated to Fudan University, Shanghai, China. , (China)
  • 5 Department of Vascular Surgery, Huadong Hospital Affiliated to Fudan University, Shanghai, China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Journal of vascular surgery
Publication Date
Sep 01, 2020
Volume
72
Issue
3
Pages
1035–1042
Identifiers
DOI: 10.1016/j.jvs.2019.11.030
PMID: 31964575
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The aim of this study was to quantitatively evaluate the changes of the foot's blood supply after endovascular treatment in patients with peripheral artery disease (PAD) using foot computed tomography (CT) perfusion. Nineteen patients who underwent endovascular treatment for PAD between January 2018 and November 2018 were included in the study. Perfusion CT scanning was performed before and after intervention with the measurement of ankle-brachial index. Regions of interest were selected from two arteries and four different tissues per foot. Perfusion maps of blood volume, blood flow, permeability surface area product, time to peak (TTP), mean transit time (MTT), mean slope of increase (MSI), Tmax, and impulse response function (IRFt0) were constructed and calculated by the perfusion analysis software. Wilcoxon signed rank test was performed on the eight parameter pairs of the limbs on the treated and untreated sides before and after intervention in the 19 patients. Differences in blood flow, MTT, TTP, Tmax, MSI, and IRFt0 on the treated side of the tissue perfusion group and statistical difference in blood flow, MTT, and MSI on the treated side of the arterial perfusion group were observed (all P < .05). Ankle-brachial index improved from 0.41 ± 0.11 to 0.76 ± 0.10 (P < .001). For the untreated side, TTP of the tissue perfusion group was significantly shortened (by 7.71 seconds) after surgery (P = .006), whereas there were no differences in the other parameters. In addition, no significant differences in parameters were observed on the untreated side of the arterial perfusion group. The average radiation dose per phase of perfusion scan was 0.00097 mSv. Moreover, the hyperperfusion zone in the plantar dermis and periosteum reappeared after revascularization. Perfusion CT is a feasible and repeatable approach for quantifying blood supply in patients with PAD. The increase of blood flow, MSI, and MTT shortening suggest blood supply improvement after revascularization in both arterial perfusion and tissue perfusion. In addition, TTP may be a sensitive indicator of blood supply changes in tissue perfusion. Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

Report this publication

Statistics

Seen <100 times