Affordable Access

Access to the full text

Quantitative assessment of the variation in IGF2BP2 gene and type 2 diabetes risk

Authors
  • Wu, Jie1
  • Wu, Junjie2, 3
  • Zhou, Yuhao4
  • Zou, Houdong5
  • Guo, Shicheng3
  • Liu, Jie3
  • Lu, Liwen6
  • Xu, Hao7
  • 1 Second Military Medical University, Department of Endocrinology, Changhai Hospital of Shanghai, Shanghai, 200433, People’s Republic of China , Shanghai (China)
  • 2 Second Military Medical University, Department of Pneumology, Changhai Hospital of Shanghai, Shanghai, 200433, People’s Republic of China , Shanghai (China)
  • 3 Fudan University, National Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Shanghai, 200433, People’s Republic of China , Shanghai (China)
  • 4 Second Military Medical University, Department of Health Statistics, Shanghai, 200433, People’s Republic of China , Shanghai (China)
  • 5 Second Military Medical University, Institute of Military Health Service Management, Shanghai, 200433, People’s Republic of China , Shanghai (China)
  • 6 Nanfang Medical University, Department of Pneumology, Fengxian District Central Hospital of Shanghai, Shanghai, 201400, People’s Republic of China , Shanghai (China)
  • 7 Zhejiang University School of Medicine, Department of Respiratory, Second Hospital, Jiefang Road 88, Hangzhou, 310009, People’s Republic of China , Hangzhou (China)
Type
Published Article
Journal
Acta Diabetologica
Publisher
Springer Milan
Publication Date
Oct 21, 2011
Volume
49
Issue
Suppl 1
Pages
87–97
Identifiers
DOI: 10.1007/s00592-011-0336-3
Source
Springer Nature
Keywords
License
Yellow

Abstract

Insulin-like growth factor 2 mRNA-binding protein 2 (IFG2BP2) belongs to an mRNA-binding protein family involved in the development and stimulation of insulin action, which has attracted considerable attention as a candidate gene for type 2 diabetes (T2D) since it was first identified through genome-wide association approach. The relationship between IFG2BP2 and T2D has been reported in various ethnic groups; however, these studies have yielded contradictory results. To investigate this inconsistency, we performed a meta-analysis of 35 studies involving a total of 175,965 subjects for two wildly studied polymorphisms (rs4402960 and rs1470579) of the IFG2BP2 to evaluate the effect of IFG2BP2 on genetic susceptibility for T2D. An overall random-effects per-allele OR of 1.13 (95% CI: 1.12–1.15; P < 10−5) and 1.09 (95% CI: 1.07–1.12; P < 10−5) was found for the two variants, respectively. Significant results were also observed using dominant or recessive genetic model. No significant results between study heterogeneity were found in most of the comparison. In the subgroup analysis by ethnicity, sample size, diagnostic criterion and mean age and BMI of cases, significantly increased risks were found for these polymorphisms in almost all genetic models. This meta-analysis demonstrated that these two common polymorphisms is a risk factor for developing T2D, but these associations vary in different ethnic populations.

Report this publication

Statistics

Seen <100 times