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Quantitative assessment of CYP11B1 and CYP11B2 expression in aldosterone-producing adenomas.

Authors
Type
Published Article
Journal
European Journal of Endocrinology
0804-4643
Publisher
Bioscientifica
Publication Date
Volume
147
Issue
6
Pages
795–802
Identifiers
PMID: 12457455
Source
Medline

Abstract

Real-time RT-PCR can be reliably used to quantify CYP11B1 and CYP11B2 mRNA levels in adrenal tIssues. Expression of CYP11B1 in hyperfunctioning zona glomerulosa suggests an additional formation of corticosterone via 11beta-hydroxylase, providing further substrate for aldosterone biosynthesis. CYP11B1 and CYP11B2 mRNA levels in APA are not related to the in vivo secretory activity of glomerulosa cells, where post-transcriptional factors might ultimately regulate aldosterone production.

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