Affordable Access

Quantitative assessment of CYP11B1 and CYP11B2 expression in aldosterone-producing adenomas.

Authors
  • Fallo, F
  • Pezzi, V
  • Barzon, L
  • Mulatero, P
  • Veglio, F
  • Sonino, N
  • Mathis, J M
Type
Published Article
Journal
European journal of endocrinology / European Federation of Endocrine Societies
Publication Date
Dec 01, 2002
Volume
147
Issue
6
Pages
795–802
Identifiers
PMID: 12457455
Source
Medline
License
Unknown

Abstract

Real-time RT-PCR can be reliably used to quantify CYP11B1 and CYP11B2 mRNA levels in adrenal tIssues. Expression of CYP11B1 in hyperfunctioning zona glomerulosa suggests an additional formation of corticosterone via 11beta-hydroxylase, providing further substrate for aldosterone biosynthesis. CYP11B1 and CYP11B2 mRNA levels in APA are not related to the in vivo secretory activity of glomerulosa cells, where post-transcriptional factors might ultimately regulate aldosterone production.

Report this publication

Statistics

Seen <100 times