Quantitative aspects of a unified model of diffusion mediated receptor--cyclase coupling.
- Published Article
- Publication Date
Jan 01, 1979
A quantitative model is presented of diffusion mediated coupling of adenylate cyclase to multivalent plasma membrane receptors which accounts for a wide range of phenomena including non linear occupation-activation plots with either positive or negative second derivatives, spare receptors, silent receptors, and negative and positive binding cooperativity. A non linear least square fit of the predicted equation for cyclase activation to available data predicts translational diffusion coefficients in the range of (10(-10) - 10(-11))cm2/s.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/218646