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Quantitative aspects of a unified model of diffusion mediated receptor--cyclase coupling.

Authors
Type
Published Article
Journal
Biophysical Chemistry
0301-4622
Publisher
Elsevier
Publication Date
Volume
9
Issue
2
Pages
163–168
Identifiers
PMID: 218646
Source
Medline
License
Unknown

Abstract

A quantitative model is presented of diffusion mediated coupling of adenylate cyclase to multivalent plasma membrane receptors which accounts for a wide range of phenomena including non linear occupation-activation plots with either positive or negative second derivatives, spare receptors, silent receptors, and negative and positive binding cooperativity. A non linear least square fit of the predicted equation for cyclase activation to available data predicts translational diffusion coefficients in the range of (10(-10) - 10(-11))cm2/s.

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