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Quantitative analysis of fosinopril sodium by capillary zone electrophoresis and liquid chromatography.

Authors
  • Lozano, R
  • Warren, F V Jr
  • Perlman, S
  • Joseph, J M
Type
Published Article
Journal
Journal of Pharmaceutical and Biomedical Analysis
Publisher
Elsevier
Publication Date
Feb 01, 1995
Volume
13
Issue
2
Pages
139–148
Identifiers
PMID: 7766720
Source
Medline
License
Unknown

Abstract

A capillary zone electrophoresis (CZE) method was developed for the quantitative analysis of fosinopril sodium. Validation parameters of the CZE method were evaluated and compared to an existing LC method. In terms of precision and sensitivity. LC performance was superior to that of the CZE method for this application. The CZE method achieved better selectivity for several degradants of interest within a much shorter analysis time than did the LC method. Effects of detection wavelength, applied voltage and buffer concentration on optimization of the CZE method are presented. Effects of diluent composition on capillary loading and peak behaviour are also discussed.

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