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Quantitation of acidosis in neonatal brain tissue using the 31P NMR resonance peak of phosphoethanolamine.

Authors
  • Corbett, R J
  • Laptook, A R
  • Hassan, A
  • Nunnally, R L
Type
Published Article
Journal
Magnetic resonance in medicine
Publication Date
Jan 01, 1988
Volume
6
Issue
1
Pages
99–106
Identifiers
PMID: 3127649
Source
Medline
License
Unknown

Abstract

31P NMR brain spectra were obtained from piglets over a range of mild hypocarbia to severe hypercarbia (PaCO225 to 198 mm Hg). The chemical shifts of the phosphoethanolamine and inorganic phosphate were used to calculate intracellular brain pH (pHet and pHpi, respectively). Both pHpi and pHet underwent parallel significant decreases during hypercarbia, corresponding to 51 and 53% pHregulation, respectively. We conclude that the chemical shift of the phosphomonoester peak in vivo can be used to measure decreases in intracellular pH in neonatal brain.

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