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Quantifying the relationship between inhibition of VEGF receptor 2, drug-induced blood pressure elevation and hypertension.

Authors
  • Collins, Teresa1
  • Gray, Kelly1
  • Bista, Michal1
  • Skinner, Matt1
  • Hardy, Christopher1
  • Wang, Haiyun2
  • Mettetal, Jerome T2
  • Harmer, Alexander R1
  • 1 AstraZeneca, Darwin Building, Cambridge Science Park, Milton Road, Cambridge, CB4, 0WG, UK.
  • 2 AstraZeneca, Gatehouse Park, Waltham, MA, 02451, USA.
Type
Published Article
Journal
British Journal of Pharmacology
Publisher
Wiley (Blackwell Publishing)
Publication Date
Feb 01, 2018
Volume
175
Issue
4
Pages
618–630
Identifiers
DOI: 10.1111/bph.14103
PMID: 29161763
Source
Medline
License
Unknown

Abstract

Taken together, these data show that the risk of blood pressure elevation is proportional to the amount of VEGFR-2 inhibition, and a margin of >10-fold between VEGFR-2 IC50 and Cav,u appears to confer a minimal risk of hypertension.

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