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Quantification of the transferability of a designed protein specificity switch reveals extensive epistasis in molecular recognition.

Authors
Type
Published Article
Journal
Proceedings of the National Academy of Sciences
1091-6490
Publisher
Proceedings of the National Academy of Sciences
Publication Date
Volume
111
Issue
43
Pages
15426–15431
Identifiers
DOI: 10.1073/pnas.1410624111
PMID: 25313039
Source
Medline
Keywords
  • Computational Design
  • Interface Evolution
  • Promiscuity
  • Protein Interaction Domains
  • Recognition Specificity

Abstract

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