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Quantification of cat's articular afferents containing calcitonin gene-related peptide or substance P innervating normal and acutely inflamed knee joints.

Authors
  • Hanesch, U
  • Heppelmann, B
  • Schmidt, R F
Type
Published Article
Journal
Neuroscience Letters
Publisher
Elsevier
Publication Date
Sep 19, 1997
Volume
233
Issue
2-3
Pages
105–108
Identifiers
PMID: 9350843
Source
Medline
License
Unknown

Abstract

In cats with an acute (32 h) unilateral knee joint inflammation the proportion of calcitonin gene-related peptide-(CGRP) and substance P-(SP) immunoreactive articular afferents, retrogradely labelled by Fast Blue (FB), were determined using immunohistochemistry. The proportion of neurons containing CGRP was significantly higher on the inflamed side (52%) than on the contralateral side (39%) and in controls (42%). However, the proportion of SP-immunoreactive articular perikarya on the inflamed side (26%) did not differ from the contralateral side (24%) and the control cats (22%). These data indicate that acute inflammation induces the synthesis of CGRP but not of SP in joint afferents.

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