Overall quality of life all domain scores were presented with transformed score (0 to 100 scale) for comparison, and the mean score was 79.7. Physical domain was the highest with a score of 58.19, social domain was 56.49, psychological domain was 48.54 and environmental domain was 46.84. A total of 64.5% had experienced a low level of perceived stigma, and only 0.6% experienced a high level of perceived stigma. Only 7% had good social support and 22.1% had low support. Social support, last CD4 count, family income per month, age, stigma and duration of treatment were determined as the significant predictors on quality of life after controlling for other factors. The factors could explain 22% of the variation in quality of life. In the absence of good social networks, peer group support, family involvement and support, reduction of stigma through multi-sectored approaches, women with HIV/AIDS will continue to suffer poor quality of life, less enjoyment and poor life satisfaction.