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Quality of life in 269 patients with poor-risk diffuse large B-cell lymphoma treated with rituximab versus observation after autologous stem cell transplant.

Authors
  • Heutte, Natacha
  • Haioun, Corinne
  • Feugier, Pierre
  • Coiffier, Bertrand
  • Tilly, Herve
  • Ferme, Christophe
  • Gabarre, Jean
  • Morschhauser, Franck
  • Gisselbrecht, Christian
  • Mounier, Nicolas
Type
Published Article
Journal
Leukemia & Lymphoma
Publisher
Informa UK (Taylor & Francis)
Publication Date
Jul 01, 2011
Volume
52
Issue
7
Pages
1239–1248
Identifiers
DOI: 10.3109/10428194.2011.566951
PMID: 21463114
Source
Medline
License
Unknown

Abstract

We aimed to assess quality of life (QoL) following front-line autologous stem cell transplant (ASCT) and the QoL relationship with rituximab maintenance, in patients with diffuse large B-cell lymphoma. Patients were then randomized to either one weekly rituximab injection for 4 weeks, or observation alone. Patients (n = 269) were given the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 questionnaires. Scales for all symptoms exhibited similar temporal patterns, with a marked increase, followed by a plateau after 1 year. The proportion of patients with a clinically significant improvement varied from 6% (constipation) to 56% (fatigue). Age, gender, and previous treatment-induced toxicities were not predictive of variations in QoL. Rituximab significantly reduced pain and symptom severity. Our results for QoL showed that patients experienced rapid recovery after ASCT in all the domains tested. Differences in QoL improvement with time were not connected with rituximab maintenance.

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