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[Qualitative and quantitative changes in phospholipid spectra of the brain of rats with corazol-induced epilepsy].

Authors
  • Martirosian, M A
  • Ovsepian, L M
  • Sarkisian, L V
  • Khanbabian, M V
  • Karag''ezian, K G
Type
Published Article
Journal
Biulleten' eksperimental'noĭ biologii i meditsiny
Publication Date
Jan 01, 1991
Volume
111
Issue
1
Pages
7–9
Identifiers
PMID: 2054481
Source
Medline
License
Unknown

Abstract

The enhancement of the sum of phospholipids in seizure period was observed during initially generalized corazol seizure in white rats' cerebral cortex. This sum fell in an hour after epileptic fit. It is noted that the maintenance of lysophosphatidylcholines and phosphatidylserines enhanced during the fit, and the maintenance of phosphatidylcholines and phosphatidylethanolamines fell either in cerebral cortex, or in cerebellum. At the same time the enhancement of the mixed fraction of sphingomyelin and phosphatidylinositide level and cardiolipins-1 in the cerebral cortex was observed. The maintenance of the latter in cerebellum fell during an hour after the attack. The quantity of cardiolipins-2 in cerebellum enhanced during the attack. It is suggested that the effect of corazol seizure leads to the enhancement of lisoforms at the expense of the intensification of disintegration of other fractions of lisoforms.

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