Affordable Access

Qualitative discrimination between cocaine and amphetamine in rats.

Authors
  • Goudie, A
  • Reid, D
Type
Published Article
Journal
European Journal of Pharmacology
Publisher
Elsevier
Publication Date
Jul 14, 1988
Volume
151
Issue
3
Pages
471–474
Identifiers
PMID: 3215271
Source
Medline
License
Unknown

Abstract

After extensive training, rats discriminated amphetamine (1 mg/kg) from cocaine (either 5, 10 or 12.5 mg/kg) in a two lever drug versus drug discrimination task. In tests with saline, selection of the cocaine lever occurred in animals trained with 5 mg/kg cocaine. At higher training doses of cocaine, a (dose-related) tendency for lever selection to be equally distributed between the two levers was seen after saline injections. These data show that, at specific pairs of doses of cocaine and amphetamine, a qualitative discrimination between the drugs develops.

Report this publication

Statistics

Seen <100 times